Leighton A Elliott

Leighton A Elliott, MD

Assistant Professor

Department: MD-HEMATOLOGY/ONCOLOGY-ONCOL
Business Phone: (352) 273-7832
Business Email: leightonelliott@ufl.edu

About Leighton A Elliott

I completed my residency training at Geisinger Medical Center in Danville, PA in a combined residency for both internal medicine and pediatrics where I was also Chief Resident. I then completed my specialty training in hematology and oncology at UF where I was also Chief Fellow. I chose to specialize in hematology and oncology due to the evolving landscape of immunotherapy and the need to improve care for the adolescent and young adult (AYA) population. I specialize in treating sarcomas – a rare cancer that affects the bones and soft tissues. As Director of the AYA Cancer Program, I work closely with our colleagues in Pediatric Oncology to optimize care for our AYA patients aged 15-45.

I aim to cure cancer using novel immunotherapies. As I believe we are close to this goal, I aim to decrease the morbidity and mortality of surgical interventions for cancer by developing therapies to work together with immunotherapy for advanced disease. We research various nanoparticles to accomplish this goal in my lab.

Outside of work, I enjoy spending time with my wife and our 7 children serving in church, playing board games, sports, and movie nights!

Board Certifications

  • Hematology
    ABIM
  • Internal Medicine
    ABIM
  • Pediatrics
    ABP

Clinical Profile

Specialties
  • Hematology
Subspecialties
  • Hematology and Oncology
Areas of Interest
  • Adult soft tissue sarcoma
  • Ewing sarcoma
  • Osteosarcoma
  • Rhabdomyosarcoma

Research Profile

Areas of Interest
  • Adolescents and Young Adults with Cancer
  • Cancer Immunotherapy
  • lipid nanoparticles

Publications

Academic Articles
2024
RNA aggregates harness the danger response for potent cancer immunotherapy.
Cell. 187(10):2521-2535.e21 [DOI] 10.1016/j.cell.2024.04.003. [PMID] 38697107.
2024
Vaccines: a promising therapy for myelodysplastic syndrome.
Journal of hematology & oncology. 17(1) [DOI] 10.1186/s13045-023-01523-4. [PMID] 38191498.
2023
Langerhans Cell Histiocytosis of the Head and Neck: Experience at a Rural Tertiary Referral Center.
The Annals of otology, rhinology, and laryngology. 132(4):431-439 [DOI] 10.1177/00034894221098466. [PMID] 35656804.
2022
Ewing Sarcoma of the 9th Rib Subsequent to Pediatric Leukemia: A Case Series
Journal of Pediatric Hematology/Oncology. 44(2):e609-e611 [DOI] 10.1097/mph.0000000000002282.
2021
Compliance with germline testing in pancreatic cancer in a rural tertiary care hospital.
Journal of Clinical Oncology. 39(15_suppl):10599-10599 [DOI] 10.1200/jco.2021.39.15_suppl.10599.
2021
Supplement: American Society of Pediatric Hematology/Oncology (ASPHO) 2021 Paper and Poster Abstracts: Severe Thrombocytopenia in a Newborn.
Pediatric Blood & Cancer. 68(S3) [DOI] 10.1002/pbc.29060.
2020
2020 ASPHO Conference Paper and Poster Index: Case series of extraosseous Ewing sarcoma associated with regionality and pediatric obesity
Pediatric Blood & Cancer. 67(S2) [DOI] 10.1002/pbc.28321.
2020
Esophageal cancer: How far is close enough?
Journal of Clinical Oncology. 38(15_suppl):e19049-e19049 [DOI] 10.1200/jco.2020.38.15_suppl.e19049.
2020
Rates of adherence to bone health guidelines for women with breast cancer treated with anti-estrogen therapy.
Journal of Clinical Oncology. 38(15_suppl):7051-7051 [DOI] 10.1200/jco.2020.38.15_suppl.7051.
2009
Simulating the fine-branch arboreal niche and exercising mice to elicit above-branch quadrupedal grasping and climbing
Lab Animal. 38(11):369-374 [DOI] 10.1038/laban1109-369.

Grants

May 2025 ACTIVE
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
Role: Principal Investigator
Funding: NRG ONCOLOGY FOU via NATL INST OF HLTH NCI
Feb 2024 ACTIVE
RNA-nanoparticle (RNA-NP) vaccine for ARMS
Role: Principal Investigator
Funding: KATE AMATO FOUNDATION

Education

MD
2017 · Trinity School of Medicine
MS Bioengineering
2010 · Mercer University
BS Biomedical Engineering
2009 · Mercer University

Contact Details

Phones:
Business:
(352) 273-7832
Emails:
Addresses:
Business Mailing:
PO Box 100278
GAINESVILLE FL 32610
Business Street:
1600 SW Archer Road
University of Florida Department of Medicine
Gainesville FL 32610