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UF Health University of Florida

Division of Hematology & Oncology

Department of Medicine in the College of Medicine

Bently P Doonan

Bently P Doonan, MD

CLIN AST PROF

Department: MD-HEMATOLOGY/ONCOLOGY
Business Phone: (352) 273-7832
Business Email: bently.doonan@medicine.ufl.edu

About Bently P Doonan

Bently Doonan, MD, MS is an assistant professor in the Division of Hematology & Oncology at the University of Florida College of Medicine. Dr. Doonan earned his undergraduate degree in biology, cum laude, from Coastal Carolina University. He then received both his Master of Biomedical Sciences specializing in cancer immunology and his medical degree from the Medical University of South Carolina.

Dr. Doonan completed an internal medicine residency and a fellowship in hematology and oncology from the University of Florida College of Medicine. During his time at UF, Dr. Doonan took on multiple leadership roles including Chief resident in internal medicine, curriculum development Gator Counsel and quality and efficiency Gator Counsel.

His clinical and research interests focus on melanoma, immunotherapy development and design, brain metastases, and identification of microenvironment targets to induce an immunogenic response in advanced metastatic disease.

Dr. Doonan is board certified in Internal Medicine by the American Board of Internal Medicine. He is a member of the American College of Physicians, the American Society of Clinical Oncology, the American Society of Hematology, the Society for Immunotherapy of Cancer and the American Association for Cancer Research.

Accomplishments

Florida ACP First Place Research category
2017 · American College of Physicians
Intern of the year in Internal Medicine
2015-2016 · University of Florida College of Medicine
Resident Teacher Award
2015-2016 · University of Florida College of Medicine

Board Certifications

  • Internal Medicine
    American Board of Internal Medicine
  • Oncology
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Medicine
Subspecialties
  • Cancer
Areas of Interest
  • Melanoma
  • Metastasis
  • Metastatic brain tumor

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-5401-2910

Areas of Interest
  • Immunogenic Response to MSS Colorectal Cancer
  • Immunotherapy Development
  • Metastasis
  • Metastatic Brain Tumor
  • Metastatic Melanoma

Publications

2022
GILT Expression in Human Melanoma Cells Enhances Generation of Antigenic Peptides for HLA Class II-Mediated Immune Recognition.
International journal of molecular sciences. 23(3) [DOI] 10.3390/ijms23031066. [PMID] 35162988.
1 citation · PubMed · Publisher’s Site
2019
Endoplasmic reticulum stress, autophagic and apoptotic cell death, and immune activation by a natural triterpenoid in human prostate cancer cells.
Journal of cellular biochemistry. 120(4):6264-6276 [DOI] 10.1002/jcb.27913. [PMID] 30378157.
2 citations · PubMed · Publisher’s Site
2018
Autophagy-dependent crosstalk between GILT and PAX-3 influences radiation sensitivity of human melanoma cells.
Journal of cellular biochemistry. 119(2):2212-2221 [DOI] 10.1002/jcb.26383. [PMID] 28857256.
9 citations · PubMed · Publisher’s Site
2015
Prostate Cancer Immunotherapy: Exploiting the HLA Class II Pathway in Vaccine Design.
Journal of clinical & cellular immunology. 6(4) [PMID] 26807308.
4 citations · PubMed
2012
A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma.
Apoptosis : an international journal on programmed cell death. 17(10):1066-78 [DOI] 10.1007/s10495-012-0745-y. [PMID] 22847295.
24 citations · PubMed · Publisher’s Site
2012
Mechanisms regulating enhanced human leukocyte antigen class II-mediated CD4 + T cell recognition of human B-cell lymphoma by resveratrol.
Leukemia & lymphoma. 53(2):305-14 [DOI] 10.3109/10428194.2011.615423. [PMID] 21854084.
18 citations · PubMed · Publisher’s Site
2011
Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients.
Journal of neuroimmunology. 232(1-2):179-85 [DOI] 10.1016/j.jneuroim.2010.09.030. [PMID] 21075457.
27 citations · PubMed · Publisher’s Site
2010
A systematic approach to virus-virus interactions.
Virus research. 149(1):1-9 [DOI] 10.1016/j.virusres.2010.01.002. [PMID] 20093154.
118 citations · PubMed · Publisher’s Site
2010
Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.
The open prostate cancer journal. 3:78-85 [PMID] 24790681.
11 citations · PubMed
2010
HLA Class II Antigen Presentation in Prostate Cancer Cells: A Novel Approach to Prostate Tumor Immunotherapy.
The Open cancer immunology journal. 3:1-7 [PMID] 24163711.
8 citations · PubMed

Grants

Jan 2022 ACTIVE
ORBIT-m: Optimal Response Biome for ImmunoTherapy in Melanoma
Role: Principal Investigator
Funding: PPD INVESTIGATOR SERVICES LLC via MICROBA

Education

Fellowship in Hematology and Oncology
2019-2021 · University of Florida College of Medicine
Residency in Internal Medicine
2015-2019 · University of Florida College of Medicine
Medical Degree
2011-2015 · Medical University of South Carolina
Master of Biomedical Sciences in Microbiology and Immunology
2008-2010 · Medical University of South Carolina
Bachelors of Science in Biology
2004-2008 · Coastal Carolina University

Contact Details

Phones:
Business:
(352) 273-7832
Emails:
Business:
bently.doonan@medicine.ufl.edu
Addresses:
Business Mailing:
PO Box 100278
 GAINESVILLE FL 32610
Business Street:
PO Box 100278
 GAINESVILLE FL 32610